Pathophysiology of Alzheimers Disease
Alzheimers disease is a progressive loss of mental function characterised by degeneration of brain tissue,including loss of nerve cells,accumulation of abnormal protein called beta amyloid and development of neurofibrillary tangles.
- Decrease in acetylcholine.
Check for symptoms:
- Forgetting recent events is an early sign,followed by increasing confusion, impairment of other mental functions,problems using and understanding language and doing daily tasks.
- People become less able to use good judgment.speech pattern may change slightly.people may use simple words rather than a specific word.they are unable to find specific word.
Cholinesterase inhibitors: Donepezil,Rivastigmine,
Drug and Dose:
- Memantine:5 mg bid
- Rivastigmine:1.5 mg bid
Counselling on side effects:
- Donepezil : well tolerated but can cause nausea, diarrhoea.
- Continuing to do challenging mental activities(learning new skills,doing crossword puzzles) well in to old age.
- Controlling hypertension
- Lowering cholesterol levels
- Consuming a diet rich in omega 3 fatty acids and low in saturated fats.
- Drinking alcohol in modest amounts